Sentence examples for mice gene knockout from inspiring English sources

In mice, gene knockout experiments show that the ZAS proteins are required for both osteoblast and osteoclast development [14] [16], and together this protein family might orchestrate postnatal skeletal development.

Recent progress in human genome wide association studies in combination with high-throughput mouse gene knockout phenotyping efforts of multiple genes and advanced conditional gene inactivation in mouse models have successfully identified genes with crucial roles in cortical bone homeostasis.

In the mouse gene knockout model IL-6 has also been shown to participate in the early induction of IFN γ production [23].

Mouse gene knockout studies indicate that all four CatSper subunits are required to mediate functional Ca2+-selective sperm currents necessary for sperm hyperactivation [12] [14], [21].

The apparent difference between the mouse gene knockout and zebrafish models suggests that important aspects of the Prion protein biology may be revealed in the zebrafish model, using morpholino (MO) mediated translation blocking [10].

Lexicon Pharmaceuticals, during the decade preceding the initiation of the IKMC program, successfully employed industrialized biology to generate and phenotype over 4 650 mouse gene knockout lines.

A number of upstream activators of JNK and p38 have been identified by cloning and transfection experiments using cells in culture and mouse gene knockout experiments.

The results of mouse gene knockout studies disagree about the degree to which mice lacking these receptors learn to drink sweeteners if given periods of exposure to sweetened water.

To provide insight into the molecular pathogenesis of ZS, mouse gene knockout models of ZS have been generated by targeted disruption of the PEX13 gene (Maxwell et al., 2003), as well as the PEX2 (Faust and Hatten, 1997) and PEX5 (Baes et al., 1997) genes.

About 15% of mouse gene knockouts are lethal; others produce unexpected handicaps.

Because most of the mouse gene knockouts were generated by individual laboratories for finding knockout phenotypes, recently duplicated genes may have been purposely avoided to minimize the experimental cost due to negative-phenotype results.