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Capecchi, M. R. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century.
Philosophe, B. & Miller, R. A. T lymphocyte heterogeneity in old and young mice: functional defects in T cells selected for poor calcium signal generation.
In control mice, functional ischemia alone was found insufficient to cause a similar degree of myofiber damage observed in mdx mice.
As in the case of Prep1 hypomorphic mice, functional inactivation of Prep1 (by cytosolic sequestration) caused a reduction in the levels of Pbx2 protein.
In these mice, functional expression of miRNAs was completely deleted.
In ApoE−/− mice, functional inactivation of TLR9 pathway resulted in attenuated atherosclerosis development, as manifested by reduced plaque burden and by decreased plaque vulnerability.
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The Mary Lyon Centre, a national facility for mouse functional genomics, opened in 2004 on the site where she worked.
Skarnes, W.C. et al. A public gene trap resource for mouse functional genomics.
These studies inform the rational design of targeted immunotherapies and facilitate translation of mouse functional DC biology to the human setting.
In 2004 the Mary Lyon Centre, which is a national facility for mouse functional genomics, was opened in order to generate mouse models of human diseases.
TCRβDMF transgenic mice were generated with the help of the mouse functional genomics Platform of the Marseille-Nice Genopole®.
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