Frozen eyes of male C57BL/6 mice from young (4 mos) and old (24∼28 mos) animals were obtained from the tissue bank of the National Institute on Aging.
The analysis of liver samples identified 123, 115, and 67 proteins that distinguished (adjusted p values ≤ 0.05) young control mice from young ob/ob, db/db, and HFD-fed mice, respectively, and also 74, 79, and 41 proteins that distinguished old control mice from old ob/ob, db/db, and HFD-fed mice, respectively (Table 1).
Analysis of muscle samples revealed 19, 22, and 7 proteins that distinguished young control mice from young ob/ob, db/db, and HFD-fed mice, respectively, and 5, 12, and 13 proteins that distinguished old control mice from old ob/ob, db/db, and HFD-fed mice, respectively (Table 1).
Microglia from old PS1-APP mice, but not from younger mice, have a decrease capacity to clear Aβ.
Young mice received blood from older mice, and old mice received blood from younger ones.
These mice are more insulin resistant than ob/ob mice from a young age, despite having less fat.
The mice from the young cohort were imaged for as long as technically feasible, limited by the clarity of the cranial window, in order to reconcile the measurements within both age cohorts in a single time series.
Three new studies found that giving old mice blood from young mice or a factor found in young blood improved the function of the aging animals' muscles and brains.
Maximum life span was increased by 1 month only in mice treated from youngest age (Table 3).
Transplantation of mouse ovaries from young donors into ovariectomized female mice increased life expectancy proportional to age of the recipient (Cargill et al., 2003).
