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Two vaccinations with doses >104 pfu also protected mice from severe weight loss after infection with influenza virus A/IND/5/05 Mice that developed severe clinical signs after H5N1 infection and that showed weight loss of more than 20% were euthanized for ethical reasons.
When we next examined the impact of a prior P. aeruginosa infection on the susceptibility of the lung to fibrosis, we were surprised to observe that prior infection protected mice from severe pulmonary fibrosis.
In the present study, we showed that a single immunization with MVA-HA-VN/04 protected mice from severe disease caused by infection with the homologous strain or the A/Indonesia/5/05 strain, especially when a high dose (108 pfu) was used.
The repetitive injection of tumour necrosis factor alpha-modulated DC loaded with bCII protects the mice from severe arthritis.
Of note, the adoptive transfer of Treg protects mice from severe signs of EAE (Platten et al, 2009).
Our study showed that β1 Aβ antibody treatment protected APP23 mice from severe dendrite degeneration in type 1 commissural neurons when treatment was started at 3 months before Aβ and dendrite pathology develop in this mouse model [ 24].
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We found that Wwox KO mice suffered from severe metabolic defect(s) resulting in growth retardation and all mice died by 3 wk of age.
Moreover, these mice suffered from severe motor defects and did not live to adulthood.
We found that Wwox KO mice suffered from severe metabolic defect(s) resulting in significant growth retardation, hypoglycemia, impaired hematopoeisis, and signs of metabolic acidosis that ultimately lead to premature death of all mice by 3 weeks of age.
These mice suffer from severe anaemia and hepatosplenomegaly.
AKO mice suffer from severe micro- and macrovascular endothelial dysfunction.
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