Viable mice from 3 762 distinct KO genes were evaluated by various combinations of DEXA (N=3 651), microCT LV5 trabecular bone (N=3 399) and/or microCT midshaft femur cortical bone (N=3 366) scans.
These seemingly inconsistent results between Fgf9 null and transgenic mice may result from distinct effect of FGF9 on different stages of skeletogenesis.
Senescence-accelerated mice (SAM) are a series of mouse strains originally derived from unexpected crosses between AKR/J and unknown mice, from which phenotypically distinct senescence-prone (SAMP) and -resistant (SAMR) inbred strains were subsequently established.
Collectively, these results indicate that the arenavirus isolated from the California mice is distinct from all other Tacaribe complex viruses.
However, the bacterial species in Marion Island mice is distinct from all other congenerics, including those previously isolated from murid rodents and pinnipeds (Fig. 2) and therefore represents a new bacterial species.
In the current study, we reasoned that by examining a diverse collection of publicly available microarray data from distinct mouse cell populations and tissues, we would be able to identify a co-expressed gene signature that was specific to the FAE and thereby gain insights into the genes that regulate the activity of the cells within it.
In the absence of histological data on the cellular composition of NALT, we have attempted to address this important issue of de novo replication vs cell migration by comparing the expression profiles of our samples with published gene sets derived from distinct mouse tissues [ 70], which provide evidence correlating particular cellular compositions with expression data.
Although the anterior segment abnormalities seen in PPCD1 mice are distinct from those of DBA/2J, it is possible that common developmental pathways are affected.
Overall, the phenotype of the bbee mice is distinct from either the bbEE or BBee mice, demonstrating that both transcription factors are crucial for the maturation of neutrophils and macrophages, as well as the innate immune system, and can at least in part compensate for each other in the single knockout mice.
These mice are distinct from the KO mouse subsequently studied at Lexicon.
