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Mice are always bred heterozygous for the targeted alleles to generate mice for both controls and experimental group.
Results from the ex vivo biodistribution studies in mice for both pretargeted cetuximab and pretargeted trastuzumab are presented in Fig. 5 (see also Additional file 1: Tables S2 and S3).
Additional studies described here show that the postulated key event of hepatocellular proliferation was observed in CD-1 mice for both PPZ and PB, and that PPZ is also a potent activator of the mouse CAR nuclear receptor.
Control mice consisted of identically treated littermate wild-type mice for both transgenic models.
Experiments carried out in three mice for both independent set of experiments gave reproducible results.
These mice were intercrossed to produce homozygous-deficient mice for both genes (bbee).
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To generate RCU mice, mice homozygous for both R26H2BCherry and Ucn3-GFP were crossed with homozygous Insulin2-Cre mice.
To investigate this phenomenon more systematically, and to quantify it for the Kb and Db alleles, we crossed B6 mice with B6.Kb−/−Db−/− (MHC−/−) mice to generate mice hemizygous for both MHC alleles (see Table 1 for full genotypic names).
DOR-eGFP mice were crossed with MOR-mcherry mice to obtain mice homozygous for both constructs.
And since you'll also be using your full-size keyboard and mouse for both machines, you won't just be more productive — you'll probably be more comfortable.
We videorecorded each mouse for both tests with an IIDC Point Grey research camera connected to a standard personal computer running Linux 2.6.18.
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