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Based on this, we studied PPI of the startle response in PRG‐1+/− (het) and wild‐type (wt) mice finding that PRG‐1+/− animals showed a significant decrease of PPI in comparison with wt littermates (Fig 5C).
Other studies have examined MEFs from separase knock-out mice, finding that chromatid disjunction was blocked without separase, but again it was not determined whether chromosome arms or the centromeres were unable to separate [39], [40].
To discount age-related effects, we analyzed 20-week-old mice, finding that the accumulation of T cell infiltrates is detectable in these young animals (Fig 5C).
Furthermore, we systematically assess the impact of standard antigen retrieval procedures on the immunoreactivity of C4F6, and related antibodies, towards mutant and WT SOD1 in fixed tissue specimens from transgenic mice, finding that standard antigen retrieval techniques greatly influence reactivity.
We compared USDs to USIs in wild-type mice, finding that USDs are louder (higher peak sound-pressure level) and longer, consistent with greater arousal in the distress condition.
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Not surprisingly, still greater declines in all imaging biomarkers was observed in severely-affected udx mice, findings that were, again, supported by our histological findings.
Our finding that GF mice are resistant to DIO, weight gain and adiposity is consistent with recent findings of Backhed [12], [13].
Notably, we did not observe an inverse relationship between vessel density and tumor size in our studies with the CD248CyD/CyD versus CD248WT/WT mice, findings that contrast with those reported in studies using CD248-deficient mice [ 21, 25].
3xTg-AD mice when compared with age-matched WT mice, a finding that supports the hypothesis that aged 3xTg-AD mice may show deficits in counteracting disease progression.
It is important to note that the peripheral blood of vascular injured mice yields more MSCs than that of control mice, a finding that is likely due to enhanced levels of granulocyte colony-stimulating factor (G-CSF) following injury.
In fact, levels of β-glucan in BALF (measured by Fungitell assay; Associates of Cape Cod, East Falmouth, MA) were similar or greater in WT mice, a finding that may reflect increased clearance as a result of enhanced lung inflammation in p47phox−/− mice (data not shown).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com