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It has previously been shown that DNL is very significantly increased in chow-fed ob/ob mice [ 18, 19] and reduced in mice fed high fat diets.
Nazıroğlu, M. et al. Apple cider vinegar modulates serum lipid profile, erythrocyte, kidney, and liver membrane oxidative stress in ovariectomized mice fed high cholesterol.
Moreover, ovariectomized mice fed high cholesterol had increased serum estrogen levels compared with those fed a normal chow.
We show here that IL-1 inhibition reduces atheroma formation and prevents the associated rise in blood pressure in Apoe−/− mice fed high fat diets.
We generated microarray gene expression data from livers of male mice fed high calorie or CR diets, and we find that CR significantly changes the expression of over 3,000 genes, many between 10- and 50-fold.
However, Apoe−/− mice fed high fat diets had increased blood pressure compared with chow fed animals, with WHC-fed mice having a greater elevation than Western fed animals (p<0.05 WHC vs Western or chow)(figure 2b).
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To characterize potentially pathogenic B-cell repertoires in this disorder, we performed high-throughput immunoglobulin (Ig) sequencing from multiple tissues of mice fed high-fat diet (HFD) and regular diet (RD).
Gault, V. A., McClean, P. L., Cassidy, R. S., Irwin, N. & Flatt, P. R. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.
The onset of insulin resistance, the sites of action, and the mechanisms through which tumor necrosis factor α (TNF-α) exacerbates the increase in adiposity and the development of insulin resistance in mice fed high-fat (HF) diet remain unclear.
Ablation of Ces1d expression in two independent NASH mouse models, phosphatidylethanolamine N-methyltransferase knockout mice fed high-fat diet, and Ldlr −/− mice fed high-fat, high-cholesterol Western-type diet, reduced liver inflammation, oxidative stress and fibrosis (Lian et al., 2012a, 2016).
Induction of ChREBP-β and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 knockout mice fed high-fructose diets, and this was accompanied by a 50% reduction in de novo lipogenesis a, 30% reduction VLDL secretion, and a 25% reduction in liver fat compared to fructose-fed controls.
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