Surprisingly, NKT cell-deficient (CD1d and Jalpha18 mice failed to develop ozone-induced AHR.
This protection was antigen specific: HSV-immunized mice failed to suppress tumours after challenge with B16.Ova cells (Fig. 4b).
We found that E-cadherin conditional knockout mice failed to survive, dying within the first 24 hours of birth.
These mice failed to activate the inflammasome in response to the 35 amino acids of flagellin or in response to Legionella pneumophila infection.
In addition, direct activation of iNKT cells with alpha-GalCer, which induced AHR in wild-type mice, failed to induce AHR in ICOS mice.
Solvent-only-treated mice failed to develop elevated TEWL values above the physiological threshold (A).
In contrast, NOD.B10-H2(b).C-Stat6 mice failed to develop glandular dysfunction, maintaining normal saliva flow rates.
These mice failed to suckle and died a day or so after birth.
Previous efforts to create mice with single-copy BRCA1 mutations had uncertain results because the mice failed to show the pattern of human cancers.
In early- (but not late-) stage infection, Irgm3 mice failed to properly control parasite replication, generated little tissue inflammation and were hyporesponsive to pentavalent antimony (Sb) chemotherapy.
In contrast, cardiomyocytes from beta-arrestin2 KO and GRK6 KO mice failed to respond to SII, but displayed preserved responses to ANG.
