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Mice expressing the unedited serotonin receptors developed normally, but mice expressing the edited version presented with several abnormalities, including growth retardation and hyperphagia.
We produced transgenic mice expressing the human CD81 protein in a wide variety of tissues.
Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase.
Jonsson, P. A. et al. Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1.
Transgenic mice expressing the human UGT1 locus (UGT1A1*1) in a Ugt1−/− background (hUGT1 32 were developed previously20.
Mindrescu, C. et al. Reduced susceptibility to collagen-induced arthritis in DBA/1J mice expressing the TSG-6 transgene.
Katherine Siminovitch and colleagues show that mice expressing the autoimmune disease associated Ptpn22 coding variant show thymic and splenic enlargement and lymphocyte and dendritic cell hyperresponsiveness.
The latter DC population was identified in mice expressing the human diphtheria toxin receptor (DTR) under transcriptional control of the endogenous langerin/CD207 promoter (langerin-DTR).
(a) Light microscopy to detect SA-β-gal-stained cells in liver sections of mice expressing the indicated molecules on day 2 post-HTVi.
Adam Packer and his colleagues created a strain of mice expressing the Channelrhodopsin protein and an ultrasensitive calcium-binding protein in neurons in the barrel cortex, the part of the brain that receives sensory information from the whiskers.
We have generated mice expressing the human apo E4 isoform in place of the endogenous murine apo E protein and have compared them with mice expressing the human apo E3 isoform.
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