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Transgenic mice expressing small amounts of Ifn-PrP (1/6th of the endogenous PrP mRNA level) were smaller than non-Tg littermates and developed mild ataxia with modest spongiform changes at 18 24 months of age.
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Cells obtained from WT mice expressed small amounts of functionally active ATGL, but the biochemical parameters of NO signaling were identical in ATGL-deficient cells.
In transgenic mice expressing anchorless PrP small amyloid-seeding PrPres aggregates appeared to be transported in the ISF, thus spreading development of cerebral amyloid angiopathy (CAA) throughout the brain.
All of these lines developed mammary tumors with a lower incidence than the original mice expressing both large T and small t antigens (SVT/t) (100, 64, 6 12 and 0% for SVT/t, SVT, SVt and SVBst-Bam, respectively) [ 57, 58], indicating many cooperating functions in the SV40 early genome.
Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I. BACKGROUND & AIMS: Growth hormone and insulin-like growth factor I (IGF-I) stimulate small bowel growth.
Significantly decreased 4R tau assembly in response to small relative amounts of 3R tau may explain why mice and rats typically express small amounts of 3R tau into adulthood [31] and do not typically develop tau pathology.
Transgenic mice expressing Col2-Tgrdw were viable and were either normal or slightly smaller than wild-type mice at birth.
We have previously generated and characterized transgenic mice expressing an Ets dominant repressor (En/Erm) with broad Ets-blocking activity in the small intestinal epithelium [ 10].
By cross-breeding with mice expressing the Cre-reporter allele Rosa26R (Soriano, 1999), Cre-mediated recombination was estimated to be ∼70% in the small intestine (Fig 1D).
Seizures were particularly common in mice expressing mutant RHEB: whereas 20% (2/10) of mice expressing RHEB1-WT developed epilepsy, all (7/7) mice expressing RHEBp.P37L and 83% (5/6) of mice expressing RHEBp.S68P developed spontaneous seizures (Fig. 4d).
High bone mass in mice expressing a mutant LRP5 gene.
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