Using single-cell nested PCR for the amplification of cDNAs, which provides both sensitivity and specificity [ 22], we found that a large proportion of the beta cells in adult, neonatal and fetal mice expressed multiple islet hormone genes.
In this study, we showed that several mouse organs express multiple prominin-1 splice variants on mRNA, indicating that these different variants probably have partially overlapping functions.
In this study, we demonstrated that mouse osteoclast precursors expressed multiple Notch receptors and ligands during osteoclastogenesis, but Notch2/Dll1 axis enhanced and Notch1/Jagged1 axis suppressed osteoclastogenesis selectively.
Bigenic and multiple transgenic mice expressing various combinations of mutant APP and mutant tau recapitulate the combined amyloid and tau-pathology of AD, but lack neurodegeneration and brain-atrophy typical for AD [14] [18].
Utilizing Affymetrix whole mouse genome gene expression microarrays, we collected gene expression data from viral (v -Abl kinase-transformed pre-B cell lines that were generated from multiple WT mice expressing an Eμ-Bcl2 transgene.
For this purpose, much effort is needed to develop and maintain multiple independent lines of mice expressing different color fluorescent proteins.
In multiple model systems, including Drosophila and mice expressing CUG repeats, coexpression of MBNL suppresses CUG-mediated toxicity (de Haro et al., 2006; Kanadia et al., 2006).
Genetic deletion of α-syn in mice results in increased levels of cerebral cholesterol, cholesteryl esters and triacylglycerols [25], whereas changes in multiple classes of phospholipids were detected in old (but not young) transgenic mice expressing human α-syn [26].
Using mice expressing channelrhodopsin (ChR2) in keratinocytes we show that blue light activation of the epidermis alone can produce action potentials (APs) in multiple types of cutaneous sensory neurons including SA1, A-HTMR, CM, CH, CMC, CMH and CMHC fiber types.
This involves creating genetically engineered mice expressing algal proteins called Channelrhodopsins in specified groups of neurons.
