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(A ) Crh-Cre +/− ; ROSA LSL-ChR2-EYFP mice express the ChR2-EYFP fusion protein in CRH-expressing interneurons of the external plexiform layer (EPL) of the main olfactory bulb (scale bar, 0.5 mm).
We first tested whether T cells that develop in HIS mice express the receptor for IL-7 by flow cytometry and observed expression levels similar to those found on normal human T cells in the peripheral blood (Figure 1b).
PS19 Transgenic (Tg) mice express the P301S mutant form of human tau and develop progressive accumulation of neurofibrillary tangles with age.
The FTL mice express the marker gene lacZ in neurons and their processes following many different stimuli, and allow the imaging of activation from the level of the entire brain surface through individual neurons and their projections.
These mice express the simian virus (SV) large T antigen under the control of the rat insulin promoter (Rip) and develop β-cell tumors in a process of multi-stage carcinogenesis.
Transgenic mutant (TGmut) mice express the mutant PRKAG2 gene (substitute of arginine for glutamine at residue 302), with transgenic wildtype (TGwt) mice expressing the normal human PRKAG2 complementary deoxyribonucleic acid (cDNA).
Although few ILCs of the skin in mice express the transcription factor RORγt, a significant fraction of skin ILCs are capable of producing IL-17A, suggesting that they are ILC3s or ILC3-like cells independent of RORγt (Yang et al., 2016).
These mice express the p53R172H mutation driven by the whey acidic protein promoter [33].
C57Bl/6 mice express the IgH-1b allelic gene and therefore express the IgG2c isotype rather than IgG2a [22], [22].
The R6/2 mice express the first exon of the huntingtin gene engineered to contain ∼150 CAG repeats.
pR5 mice express the longest human tau isoform carrying the pathogenic P301L mutation, under control of the murine Thy1.2 promoter that drives neuronal expression of the transgene.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com