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Lastly, recent evidence suggests that female estrogen-deficient mice express reduced telomerase activity, and that hormone replacement (HR) restores the levels to those of control mice.[24] In light of these findings, we reran the above analyses removing the two participants in our sample who were undergoing HR therapy.
Moreover, fibroblasts from Nrf2−/− mice express reduced levels of HO-1 mRNA [55].
RIP140 heterozygous mice express reduced levels of RIP140 in the gastrocnemius and in the edl (data not shown), resulting in intermediate levels of mitochondrial activity as judged by SDH staining.
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Intercrosses and 129/Ola mice expressing reduced endoglin also showed lower plasma TGF-β1 levels than control.
Transgenic mice expressing reduced levels of VEGF develop late-onset motor neuron degeneration, reminiscent of amyotrophic lateral sclerosis (ALS), whereas reduced levels of VEGF have been implicated in a polyglutamine-induced model of motor neuron degeneration.
To elucidate this discrepancy we generated hypomorphic mice expressing reduced β1 integrin levels on keratinocytes that developed similar, but less severe defects than mice with β1-deficient keratinocytes.
This hypothesis was confirmed by a series of studies we conducted recently in dcc heterozygous mice showing that mice expressing reduced levels of DCC exhibit profound changes in mesocorticolimbic DA organization and function in adulthood.
Nevertheless, these BALB mice expressed reduced place-preference responses.
Notably, however, mice expressing increased levels of STIP1 show no major phenotype when examined using a range of behavioral tasks, whereas mice expressing reduced levels of STIP1 exhibit attention deficits and are hyperactive.
Olfactory function has been shown to be abnormal in MPTP-treated rodents (Schintu et al. 2009), transgenic mice expressing α-synuclein under a neuronal regulatory element derived from the Thy1 gene (Thy1-αSyn Thy1-αSyn et al. 2008), and mice expressing reduced levels oFlemingeticulal monoamine transporter (VMAT) (Taylor et al. 2008).
Results Here, to investigate the potential involvement of STIP1 in ASD, the authors examine mice that express reduced (50%) or increased (fivefold) levels of STIP1.
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