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We show that DAT-KO/HAD-Tg mice express only 8.5% of WT DAT levels in the striatum.
We have used genetically engineered NMDA receptor NR1+/− mice in which the gene for the NR1 subunit was modified in such a way that these mice express only 50% of the NR1 subunit.
APPPS1 mouse model expresses 'Swedish' mutant APP and M146L mutant presenilin [28] whereas R1.40 mice express only 'Swedish' mutant APP [29].
The naturally occurring Shp1 mutation observed in the motheaten (me) mice was discovered in 1975 [22], and heterozygous Shp1me/+ mice express only 50% of the Shp1 protein in all tissues.
Olfactory sensory neurons (OSN) in mice express only 1 of a possible 1,100 odor receptors (OR) and axons from OSNs expressing the same odor receptor converge into ∼2 of the 1,800 glomeruli in each olfactory bulb (OB) in mice; this yields a convergence ratio that approximates 2∶1, 2 glomeruli/OR.
Thus, APPα/α knockin mice express only secreted APPsα from the endogenous APP promoter.
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But, cells that show DNA-recombination co-expressed NCre and CCre, since in mice expressing only either NCre or CCre no recombination could be observed.
ZNF148 (alias ZBP89) was originally reported as a gastrin gene expression repressor [28], [29] and recently, studies of mice expressing only ZBP89-delta-N showed significant growth delay and a reduction of viability [30].
Bred to a Ptbp2 knockout, the transgene allowed us to compare the developmental and molecular phenotypes of mice expressing only PTBP1, only PTBP2, or neither protein in the brain.
To determine if APOE4's action resulted from an isoform-specific difference in effective levels of the apolipoproteins, we generated mice expressing only a single allele of APOE3.
Stimulated peritoneal macrophages from APOE-transgenic replacement (APOE-TR) mice expressing only human apoE3 or human apoE4 protein isoforms were utilized as mouse models to investigate the role of apoE protein isoforms and gender in the regulation of oxidative stress.
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