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Tg APParc mice express human APP (695 isoform) under the mouse Thy1.2 expression cassette.
For example, in contrast to the situation in humans, only a subpopulation of the monocytes of the transgenic mice express human FcαRI, and peritoneal macrophages and platelets exhibit no expression [ 19].
These mice express human APP 770/751 and 695 under the PDGFβ promoter [58].
LRRK2 transgenic mice express human LRRK2 at 3-5-fold the level of endogenous LRRK2 (Figure 1C and S1).
Tg2576 mice express human APP containing the familial Alzheimer's disease (FAD) Swedish mutation, which results in elevated levels of Aβ peptides [29].
[12] These mice express human PrP under the regulation of the murine promoter sequences, and survive for the same lifespan as non-transgenic mice of the same genetic background (129Ola) with no adverse effects and no features of spontaneous TSE disease.
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MUC1.Tg mice expressing human MUC1 from the human MUC1 promoter, homozygous for the transgene expression, were originally developed on an H2-k background (Peat et al, 1992).
Using RT-PCR, immunohistochemistry and immunofluorescence, we show that transgenic mice expressed human betacellulin exclusively in β-cells.
Stem cell gene transfer was efficient and nearly all red cells in transplanted mice expressed human γ-globin.
Transgenic mice expressing human VAP-1 on endothelium showed a higher signal in chemically induced ear inflammation, in comparison to the control site, and to VAP-1 deficient knockout mice.
DR2bxPSA F1 male mice expressing human PSA and HLA-DRB1*1501 transgenes were vaccinated with virus-like particle vector encoding PSA (VLPV PSA) followed by the challenge with Transgenic Adenocarcinoma of Mouse Prostate cells engineered to express PSA (TRAMP PSA).
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