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B. ovatus has also been reported to protect germ-free and conventional mice, exposed chronically to dextran-sodium sulphate (DSS), from bleeding, development of intestinal inflammation and death [ 52].
The goal of this study was to examine mRNA and protein expression changes in the lungs of mice exposed chronically to environmentally relevant concentrations of As in the food or drinking water, specifically examining the hypothesis that As may preferentially affect gene and protein expression related to immune function as part of its mechanism of toxicant action.
The effect on female mice exposed chronically for 10 weeks before conception, but not during pregnancy, showed increased transcriptional silencing of the agouti yellow viable allele (A vy ) in the offspring, in a similar trend to those exposed during pregnancy [ 39].
We have shown that mice exposed chronically (4 6 months) to cigarette smoke had increased BALF inflammation, peripheral airspace enlargement, impaired lung function and had reduced body weight, fat mass, hindlimb skeletal muscles mass (gatrocnemius, tibialis anterior and gastrocnemius muscles), grip strength (index of muscle strength) and aerobic endurance [ 105– 105].
Interestingly, despite the reduced sensitivity of pulmonary arteries to Kv7 modulators in mice with PH, the Kv7 activator, flupirtine, was able to return pulmonary artery pressure to normal, and it was able to prevent the development of HPH in mice exposed chronically to hypoxia (35).
Similar(55)
ApoE−/− mice were exposed chronically to PBS or SWCNT (four instillations of SWCNT at 20 μg/mouse every other week for 8 weeks) and fed a regular chow diet (regimen 1) or a fat chow diet for 4 weeks, followed by regular chow for 4 weeks (regimen 2).
We carried out global transcriptional profiling of lung samples from adult male mice exposed sub-chronically to MTS and sacrificed 3 hours following the final cigarette exposure or subsequent to 6 weeks of smoking cessation.
In addition, rats were exposed chronically (1st 11th week) to a variety of mild unpredictable stressors.
Adults living in countries such as Malawi have been exposed chronically to mycobacterial antigens since childhood.
An estimated 25 40 million people have been exposed chronically since the late 1970s (Ahsan et al. 2000).
Workers exposed chronically to PAHs should have serum immunoglobulins monitored regularly.
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