In particular, Twist1 appeared to dampen inflammation triggered by TH1 memory cells in mice experiencing delayed-type hypersensitivity and antigen-induced arthritis through the specific targeting of TNFα, IL2, IFNγ, SOCS1, SOCS2, IL1R decoy and Jak2.
Studies from his laboratory and others indicate that compared with ordinary mice, the dwarfs experience delayed development of osteoarthritis, cataracts, memory problems and age-related changes in the immune system.
Patients encountering these problems experience delayed care pathways and delayed adjustment to life with a chronic disease [ 17].
Axl KO mice experience enhanced inflammation and delayed myelin removal in EAE-mice [ 49], and fewer mature oligodendrocytes and more axonal damage in cuprizone induced demyelination [ 48].
Bmp2 null mutant mice experience embryonic lethality between E7.0 and E10.5 with severely delayed, ectopic or absence of cardiac development (Zhang and Bradley, 1996).
Compared to controls, the mice experienced a severe delay in the migration of neurons in their brains, leading to abnormal brain development.
In mSOD1 mice, similarly to WT mice, delayed firing motoneurons are larger than immediate firing ones.
The loss of CX43 (responsible for coordinating contractions in myometrial cells during labor) in smooth muscle tissues leads to slightly delayed parturition, even though these mice experienced normal upregulation of OXTR and progesterone withdrawal [ 31].
In Mmp9−/− mice, the delayed removal of hypertrophic cartilage correlated with a delay in ossification.
Onset of intestinal cancer in Kaiso-deficient mice is delayed compared to wild-type mice [16].
