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RAG1-/ recipients receiving CD4+CD45RBhigh T cells from C57BL/6 mice exhibited weight loss and intestinal inflammation commencing between day 30 and 40 after transfer (Figure 3A C).
In contrast, the other affected mice exhibited weight loss and hypokinesia.
This is the longest time for which K14MycAER mice could be treated, because the epidermis became overtly fragile and flaky, and mice exhibited weight loss and dehydration.
Treatments were very well tolerated, except for the combination treatment group of F8 TNF with doxorubicin against WEHI-164 tumours, where mice exhibited weight loss up to 15%.
Conversely, those inoculated with the brain homogenate of the Ka/W-affected mice exhibited weight loss and hind-limb ataxia after an incubation period of 255.8 ± 28.2 days.
Similar(55)
For example, steady-state Nrf2 KO mice display various inflammatory disorders, Gclc KO mice are lethal, and Gclm KO mice exhibit weight loss.
In contrast, after an incubation period of 457 ± 21.1 days, the other disease-affected mice (15) exhibited weight loss, hypokinesia, and uncoordinated hind-limb movements; the prion responsible for these symptoms was designated as the Ka/scrapie weight-loss-type (Ka/W) prion.
As expected wild type C57BL/6 mice exhibited severe weight loss and intestinal inflammation following acute DSS administration (Figure 1A).
Beginning at approximately 10 weeks of age, R6/2 mice exhibited significant weight loss and by 14 weeks the vehicle-treated R6/2 mice were approximately half the size of wild-type littermates.
ptpn11 fl/fl ert2-cre mice exhibited marked weight loss prior to death (Fig. 1B).
Both TNHFD Elovl6 KO mice and 12MO Elovl6 KO mice exhibited increased weight gain without increased food intake.
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