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Although no changes in LTP were evident our mice exhibited significant learning deficits.
Results showed that Cntnap2 KO mice exhibited significant deficits in working and reference memory during the acquisition period of the task.
At the end of the treatment, the aortic banding-treated mice exhibited significant elevations in cardiac remodeling, characterized by an increase in left ventricular weight relative to body weight, an increase in the area of collagen deposition, an increase in the mean myocyte diameter, and increases in the gene expressions of the hypertrophic markers atrial natriuretic peptide (ANP) and β-MHC.
The OVX mice exhibited significant increases in body weight, visceral, and inguinal fat mass compared with sham mice.
S. pneumoniae-infected WT and PAI-1−/− mice exhibited significant changes in compliance when compared to the saline controls (p = 0.03 versus 0.01 respectively).
The WT-STZ treated mice exhibited significant decreases in axonal transport rates as compared to the WT, Figure 1A.
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This laboratory has previously shown that calvarial osteoblasts isolated from TIEG1 KO mice exhibit significant delays in differentiation and a reduced ability to mineralize matrix [11].
Accordingly, PPARα KO mice exhibit significant reduction of atherosclerotic lesions, delayed wound healing, and delayed liver regeneration [14], [15], [36], due to overt inflammatory processes.
Remarkably, these mice exhibit significant increases in muscle mass despite the fact that the circulating levels of myostatin protein in these mice are dramatically increased compared to wild type mice.
As shown in Figure 1C, when atropine is applied prior to testing, all genotypes (including TKO mice) exhibit significant BLA, spending more time in the dark BH when the FH is illuminated.
GRIK2 knock-out mice exhibit significant reduction in anxiety and fear memory (Ko et al. 2005).
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