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In our studies, control mice exhibited robust rhythms in ECG parameters including RR, PR and QTc.
DAT KD mice exhibited robust, reproducible changes in each of the four outcomes, including increased transitions, rearings, and holepokes, and reduced spatial d, vs. WT littermates.
As expected, GF mice exhibited robust deficits including social avoidance (GF × chamber interaction: F 1,20)=12.41, P<0.001; Figures 1a c), and diminished preference for social novelty relative to conventionally colonised (CC) mice (GF × chamber interaction: F 1,20)=4.45, P<0.05; Figures 1d f).
In response to methacholine challenge, control B6 mice exhibited robust airway hyperreactivity (Fig. 5A).
All Group 1 mice exhibited robust food anticipatory running, beginning 2 4 h prior to mealtime (Fig. 2a b).
As expected, the conditioned mice exhibited robust freezing when the animals were re-exposed to the original shock chamber (Fig. 1E and 1G).
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Under typical experimental conditions, neither LDL receptor nor apoE KO mice exhibit robust occlusive coronary artery disease associated with myocardial infarction, heart dysfunction and death during the first six months of life (see for example [2]).
19, 26, 28, 29 These mice exhibit robust epileptic activity and have dysregulated gamma activity.
Male mice exhibit robust mounting behaviors towards sexually mature females in the presence of estrus female urine (Dixon and Mackintosh, 1975; Ingersoll and Weinhold, 1987).
However, again we were unable to generate ES cells or mice exhibiting robust widespread reporter activity (A.-K.H. and V.E. Papaioannou, unpublished observations).
Tg-SwDI mice exhibit robust accumulation of both vascular and parenchymal Aβ with predominance of Aβ40 over Aβ42 in the perivascular/vascular areas without apparent microhemorrhage or BBB leakage at 15 months of age.
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