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The specific SA129-treated mice exhibited only a modest reduction of both clinical scores (~25%) and ankle thickness (0.1 mm) at day 8.
In addition, while mRNA expression of α-SMA in the lungs of WT mice gradually but significantly increased, Ninj1 KO mice exhibited only a slight increase in α-SMA expression (Supplementary Fig. S2B).
Despite the clear effects of Wnt5a on DA differentiation in both gain and loss of function experiments in vitro [32], [54], Wnt5a−/− mice exhibited only a mild and transient DA differentiation phenotype in vivo.
In contrast, Scrib Crc /+; Celsr1 Crsh /+ mice exhibited only 8% penetrance of craniorachischisis (n=1/12).
Nonetheless, obese LFD-fed IL-1RI−/− mice exhibited only moderate glucose intolerance, negligible adipose inflammation, and preservation of adipose insulin sensitivity compared with age-matched HFD counterparts.
Perhaps surprisingly, the bim−/− bad−/− mice exhibited only slightly greater lymphadenopathy than the bim−/− animals, and their resting lymphocytes were no more resistant to cytokine deprivation than the Bim-deficient cells.
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Nevertheless, mice exhibiting only a modest decrease in HNF4α levels displayed a detectable reduction in HBV RNA and DNA levels while maintaining virtually normal growth and glucose homeostasis (Figure 1).
Interestingly, IL-6 deficient mice exhibit only a partly impaired APP production which suggests a redundant function for the IL-6 cytokine family of cytokines which share the common signalling receptor gp130 [6], [6].
In contrast the pcd mutant mice exhibit only walk, reaching a maximum speed of 0.25 m/s.
In contrast, ATR+/- mice exhibit only a small decrease in survival but tumor incidence is increased [ 12].
These data indicate that 1-d-old KI mice exhibit only LV dilation and dysfunction without LVH.
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