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Hdac6 transgenic mice exhibited normal fertility and sex ratio.
PI4KIIα TG mice exhibited normal general health, viability, fertility, and body composition (data not shown).
Compared to wild-type (WT) mice, TNFR1- and TNFR2-knockout (KO) mice exhibited normal heat sensitivity and unaltered excitatory synaptic transmission in the spinal cord, as revealed by spontaneous excitatory postsynaptic currents in lamina II neurons of spinal cord slices.
These endothelial-specific CD146-deficient mice exhibited normal development, suggesting that CD146 is dispensable for vasculogenesis in the process of embryogenesis; these animals had the ability to reproduce, which also suggests that CD146 does not play an essential role during physiological angiogenesis in adult mice, such as the adult female reproductive cycle.
The mRGC-ablated mice exhibited normal outer retinal function.
The cerebellum of the mutant mice exhibited normal foliation and laminated cortical structures (Fig. 1D).
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Wild-type mice exhibited normal-appearing vasculature and parenchyma in the cerebellum and normal nuclei and cytoplasm in cortical neurons.
Wang, S. et al. Polycomblike-2-deficient mice exhibit normal left-right asymmetry.
Aldh2-deficient mice exhibit normal bone mass but significantly reduced bone mineral density following alcohol consumption32 and increased cortical bone mineral density in the absence of drinking alcohol33.
These mice exhibit normal insulin sensitivity but decreased food intake and locomotor activity, resulting in decreased energy expenditure.
Importantly, HO-2−/− mice exhibit normal breathing patterns with normal arterial CO2 tension and retain the intact alveolar architecture, thereby excluding hypoventilation and shunting as causes of hypoxemia.
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