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In contrast, the ECM in CXCR5−/− mice exhibited large areas with a coarse network of individual collagen fibrils, and finer networks of proteoglycans with associated filaments (Fig. 6G), suggesting deranged ECM.
Using androgen-insensitive murine prostate carcinoma RM1 cells, Ribeiro et al. recently reported that ob/ob mice, which lack leptin, and diet-induced obese mice exhibited large tumors.
Elastase-perfused rats and AngII apoE −/− mice exhibited large reductions in circumferential cyclic strain and mean blood flow velocity over 28 days.
By 3 weeks, WT/R49Cneo mice exhibited large vacuoles in the cortical region 100 μm from the lens surface, and by 3 months posterior and nuclear cataracts had developed.
In striking contrast, however, both the nose and the tail of pcd mice exhibited large side-to-side oscillations during the locomotor cycle (compared to size-matched controls: nose F(13.48,1) = 5.49, p < 0.05, tail F(415,1) = 91.01, p < 0.001).
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Indeed, IL-1RI KO mice exhibited larger lesions compared with WT animals, the latter of which only presented with mild cerebritis.
First, whereas diethylamine-extractable ('soluble') pools of endogenous Aβ are relatively unchanged, CatD-null mice exhibit large increases in guanidinium-extractable ('insoluble') Aβ [ 33].
When compared with wild-type controls, these mice exhibit larger phase advances to a short late-night light pulse and larger delays to long 12 h light pulses that span the whole subjective night.
These results suggest that although DKO mice exhibit larger lesions, their atheroma composition (Fig. 6L) is favorably changed to a more stable plaque phenotype.
For example, muscle from wild-type mice show only a modest decrement in force after eccentric contractions, whereas muscle from mdx mice exhibits large deficits in force, as well as membrane instability and loss of intracellular enzymes.
CD8+ T cells from MP-immunized mice also exhibited larger, more robust cytokine secretion, and all of these trends persisted for at least 6 weeks without boosting.
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