Interestingly, GDF11-treated mice exhibited increased food intake compared to the vehicle treatment (Supplementary Fig. S4b).
Adult Bmp8b TG mice exhibited increased energy expenditure (EE) in response to NE injection compared to wild-type (WT) littermates, consistent with greater thermogenic capacity (Fig. 1a).
Concomitantly, liver Arg2-deficient db/db mice exhibited increased neutral lipid accumulation, as determined by routine histological and Oil Red O analyses (Fig. 7b).
We also verified that Gal-3−/− mice are more susceptible C. neoformans infection, and demonstrated that only Gal-3+/+ mice exhibited increased tissue content of IL-17/IL-23 IL-17/IL-23 IL-17/IL-23
Dys−/− mice exhibited increased compulsive and impulsive behaviors compared to control littermates suggesting the inability to suppress incorrectly-timed responses underlies their increased time to acquisition.
At 6 7 months, a subset of transgenic mice exhibited increased seizure susceptibility, along with an increase in IIP-MF volume (∼30%).
Unexpectedly, Ctr1(hrt/hrt) mice exhibited increased serum Cu levels and a concomitant decrease in hepatic Cu stores.
Consistent with this idea, miR-150−/− mice exhibited increased Gpnmb expression.
Furthermore, compared to STZ-WT, STZ-KO mice exhibited increased numbers of inflammatory monocytes in the bone marrow and impaired homing of monocytes to the spleen.
We identified that Brg1/Brm double-mutant mice exhibited increased mitochondrial biogenesis, increases in 'mitophagy', and alterations in mitochondrial fission and fusion that led to small, fragmented mitochondria.
All mice exhibited increased cytokine production as compared to naïve RAG1-/ controls (Figure 3D F).
