Moreover, in 2009, Miller, Harrison and colleagues showed that mixed inbred mice treated with rapamycin at a relatively late age (600 days) exhibited extended lifespans [ 2].
Both of these mutants also exhibited extended lifespan in our CLS assay.
Furthermore, mouse models exhibiting extended lifespan, i.e., Klotho, Snell and Ames dwarf mice share characteristics of low levels of endogenous oxidative stress and resistance to oxidative stress [ 14, 15, 45, 49, 50].
On the other hand, mutant mice exhibiting reduced GH/IGF1/insulin secretions exhibit extended life span (Brown-Borg et al. 1996; Kurosu et al. 2005).
The phenotype of Dgat1−/− mice is similar to that of mice lacking insulin receptors in WAT, which are also lean, have increased energy expenditure and food consumption and exhibit extended longevity [ 31, 32].
Many, but not all, mitochondrial respiration mutants exhibit extended lifespan [ 8, 9, 104, 152].
Administration of antioxidants to Atm −/− mice exhibited a variety of beneficial effects, including extended lifespan, reduced tumorigenesis and improvement of motor deficits [13,14,72].
In contrast, Col18a1 −/− mice exhibited substantial levels of lipid accumulation with signs of degeneration extending into the mid and periportal zones (Fig. 2D,E).
The present study extends those findings by showing that macrophages derived from Fpr2−/− mice exhibited lower levels of chemo- and cytokines compared with wild-type cells.
You probably won't be surprised to learn that the campylobacter-infected mice exhibited more anxiety when navigating a maze than the control mice.
