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These mice exhibited dramatically increased bone formation [30].
On the Rac1Wt/- background, LSL-K-RasG12D K14-Cre LSL-K-RasG12D K14-Cre LSL-K-RasG12D K14-Cre LSL-K-RasG12D K14-Cre an ERtended micean lifexhibited75 dramaticallyenting a ∼50% increasmallerurvival, indicative orallower growing oral papillomas (Figrowths).
In contrast, VEGF-Trap- or Tie2-Fc-treated mice showed decreased pathological manifestations, and DAAP-treated mice exhibited dramatically reduced pathological abnormalities.
The neuroprotective effects of fibroblast growth factor 2 (FGF-2) following MCAO may also be mediated in part by BDNF; FGF-2 null mice exhibited dramatically larger infarct volumes than wild-type littermates and a diminished postischemic induction of hippocampal BDNF and TrkB mRNA [ 30].
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Brown preadipocyte cell lines from IR KO mice exhibit dramatically impaired differentiation [22].
In contrast to Akt1-deficient mice, late-pregnant Akt1-/; Akt2+/- mice exhibit dramatically reduced Prlr-Jak-Stat5 signaling, as well as markedly reduced milk protein expression, lactose levels, lipid synthesis, expression of the terminal differentiation marker Npt2b, and mTOR activity.
In contrast, MTMR14 KO mice exhibited a dramatically exacerbated accumulation of visceral adipose tissue (Fig. 3a).
The γ3 -/- mice exhibited a dramatically lower incidence of irreversible destruction of glomeruli.; instead, the majority of the glomeruli in these mice revealed chronic endocapillary hypercellularity.
Nude mice inoculated subcutaneously with SMMC7721/Ad-STK33-C cexhibitedbitedramaticallyly reduced tumour volumes compared with mice receiving SMMC7721/Ad-GFP SMMC7721/Ad-GFPSTK33-N cells (figure 7B).
Although ischemic damage compared with wild-type mice was not significantly altered in mice lacking either IL-1a or IL-1b alone, mice lacking both forms of IL-1 exhibited dramatically reduced ischemic infarct volumes compared with wild type (total volume: 70%; cortex: 87% reduction) [ 59].
The mice inoculated with HKCL2/STK33 shRNA and SMMC7721/STK33 shRNA cells exhibited dramatically reduced tumour volumes compared with those receiving HKCL2/Ctrl shRNA and SMMC7721/Ctrl shRNA cells (figure 2F).
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