Cells flushed from the ankles of arthritic WT mice displayed citrullinated histones, a hallmark of PAD4 activity, and NET formation, while those from PAD4 KO mice exhibited no detectable histone citrullination or NET formation, as detected by anti-H4Cit3 and 4',6-diamidino-2-phenylindole (DAPI).
In addition, Gγ7-mCrePR mice exhibited no detectable TUNEL signals in the striatum upon RU-486 injection (data not shown).
63% of the ApoE single knockout mice exhibited clearly detectable areas of distinct COMP immunoreactivity in inflammatory and/or fibrous plaques.
Pinpointing the functional role of adiponutrin was also confounded when PNPLA3-deficient mice exhibited no detectable phenotype in lipid, lipoprotein, or energy metabolism (Basantani et al., 2011; Chen et al., 2010).
The samples exhibited detectable levels of p21 with c-Ha- anti-ras-21 mouse monoclonal antibody and levels of p62 with anti-fos-62 rabbit polyclonal antibody.
The recombinant abalone GSR (rAbGSR) exhibited detectable activity in a standard glutathione reductase activity assay.
Only a few birds exhibited detectable neurological disorders, such as severe ataxia and torticollis.
But still none of them exhibited detectable levels of neutralization activity against VSV-G control.
Interestingly, not all sub-1 T1 lines carrying the SUB gSUB EGFP reporter exhibited detectable expression (20/50).
None of the transplastomic plant lines exhibited detectable phenotypic changes in their development or morphogenesis.
