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Exact(6)
Interestingly, IL-6 deficient mice exhibit only a partly impaired APP production which suggests a redundant function for the IL-6 cytokine family of cytokines which share the common signalling receptor gp130 [6], [6].
In contrast the pcd mutant mice exhibit only walk, reaching a maximum speed of 0.25 m/s.
In contrast, ATR+/- mice exhibit only a small decrease in survival but tumor incidence is increased [ 12].
These data indicate that 1-d-old KI mice exhibit only LV dilation and dysfunction without LVH.
Unexpectedly, both ABIN-1-deficient and ABIN-2-deficient mice exhibit only slightly increased or normal NF-κB responses, respectively, possibly reflecting redundant NF-κB inhibitory activities of multiple ABINs [ 55, 56].
Joseph et al (2008) recently showed that neural crest stem cells do not persist in Nf1; p53 mutant mice; MPNST cells derived from these mice exhibit only some neural crest-like features (Joseph et al, 2008).
Similar(54)
Nevertheless, mice exhibiting only a modest decrease in HNF4α levels displayed a detectable reduction in HBV RNA and DNA levels while maintaining virtually normal growth and glucose homeostasis (Figure 1).
Despite the clear effects of Wnt5a on DA differentiation in both gain and loss of function experiments in vitro [32], [54], Wnt5a−/− mice exhibited only a mild and transient DA differentiation phenotype in vivo.
In contrast, Scrib Crc /+; Celsr1 Crsh /+ mice exhibited only 8% penetrance of craniorachischisis (n=1/12).
Nonetheless, obese LFD-fed IL-1RI−/− mice exhibited only moderate glucose intolerance, negligible adipose inflammation, and preservation of adipose insulin sensitivity compared with age-matched HFD counterparts.
Interestingly, no differences in PR (Fig. 4a c) staining were observed in the mammary glands from asPR-treated, scPR-treated, or control mice, but glands from RU 486-treated mice exhibited only isolated PR immunoreactivity (Fig. 4d).
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