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These mice exhibit normal insulin sensitivity but decreased food intake and locomotor activity, resulting in decreased energy expenditure.
Importantly, HO-2−/− mice exhibit normal breathing patterns with normal arterial CO2 tension and retain the intact alveolar architecture, thereby excluding hypoventilation and shunting as causes of hypoxemia.
However, AC3−/− mice exhibit normal ß-adrenergic stimulation of lipolysis.
On the other hand, CaMKIV KO mice exhibit normal performance in the passive avoidance test and spatial learning tasks.
Interestingly, the mutant mice exhibit normal performances in the conditioned place aversion induced by aversive air puffs.
Together, these data demonstrate that despite biochemical destabilization of the DGC and substantial muscle necrosis, adbn−/− mice exhibit normal skeletal muscle function.
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Hdac6 transgenic mice exhibited normal fertility and sex ratio.
PI4KIIα TG mice exhibited normal general health, viability, fertility, and body composition (data not shown).
These endothelial-specific CD146-deficient mice exhibited normal development, suggesting that CD146 is dispensable for vasculogenesis in the process of embryogenesis; these animals had the ability to reproduce, which also suggests that CD146 does not play an essential role during physiological angiogenesis in adult mice, such as the adult female reproductive cycle.
The mRGC-ablated mice exhibited normal outer retinal function.
The cerebellum of the mutant mice exhibited normal foliation and laminated cortical structures (Fig. 1D).
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mice exhibit myopathy
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