Sentence examples for mice exhibit marked from inspiring English sources
Leptin-deficient mice exhibit marked obesity, hyperphagia, insulin resistance, hypothermia and increased food efficiency [40], whereas iNOS knockout mice are resistant to diet-induced obesity, showing reduced epididymal fat pads and increased body temperature [26], [33].
Liver-specific SMAD4 (the common downstream mediator for all TGF-β superfamily ligands) knock-out mice exhibit marked iron accumulation and fail to increase hepcidin expression in response to TGF-β1, BMP-4, IL-6 or iron overload, suggesting a common role for SMAD4 in the manifold pathways of hepcidin regulation [14].
Of note, mutant Mn-SOD heterozygous knockout mice exhibit marked sensitization of the mitochondrial permeability transition pore (mPTP) and premature induction of apoptosis.
Recent studies have linked osteocalcin to improved glycaemic handling in tissues[ 31], and osteocalcin knockout mice exhibit marked insulin resistance and an adverse metabolic phenotype[ 32].
Mice heterozygous for the deletion of the TGF-β1 gene (tgfβ1+/-) have a 50% reduction in levels of TGF-β1 in artery walls and, when fed a cholesterol-enriched diet, such mice exhibit marked deposition of lipid in the artery wall as compared with wild-type mice [ 9].
In contrast the Tau4RTg2652 mice exhibit marked but highly variable accumulation of aggregated tau in the detergent soluble (RIPA) and detergent insoluble (FA) fractions.
Demonstrating the sensitivity of the paradigm to genetic factors, C57BL/6J and DBA/2J mice exhibited marked differences in discrimination and reversal learning.
These mice exhibited marked vulnerability to motor neuron loss after axonal injury [ 8].
ptpn11 fl/fl ert2-cre mice exhibited marked weight loss prior to death (Fig. 1B).
Paws of hTNFtg mice exhibited marked activation of both p38MAPKα and ERK (Fig. 1a,c) compared with wild-type mice.
In comparison, the treated mice exhibited marked improvement of the cutaneous lesions and reduction of overall parasite load.
