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The E-Selectin ligand-1 (ESL-1) knockout mice exhibit higher TGFβ bioavailability, and show shortened growth plate and growth retardation [36].
These data showed that CD36−/− mice exhibit higher levels of plasma cholesterol than WT mice and this difference is exaggerated upon feeding a cholesterol rich diet.
Anti-HNE staining demonstrated that similar to plasma, wound tissue of db/db mice exhibit higher levels of oxidative stress which is ameliorated following NAC supplementation (Fig. S1B).
Clecsf8−/− mice exhibit higher bacterial burdens and increased mortality upon M. tuberculosis infection.
This is noteworthy, because IL-22−/− mice exhibit higher levels of collagen type II-specific and total IgG antibodies during CIA [ 26].
These results, along with the decreased adiposity and resistance to diet-induced obesity, suggested that BACE1 −/− mice exhibit higher energy expenditure.
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Compared to C57BL/6 mice, C58 mice exhibit high rates of spontaneous hindlimb jumping and backward somersaulting reaching adult frequencies by 5 weeks post-weaning and adult temporal organization by 2 weeks post-weaning.
For example, both MaD1 and Outbred-S mice exhibit high maternal defense (protection of offspring) against a male intruder.
It is thus interesting that B6 mice exhibit high levels of sociability, social motivation and social reward relative to BALB mice.
Also, it has been reported that MSCs isolated from diabetic mice exhibit high gene expression level of senescent (p16INK4, p66shc, p53) and apoptotic (Bax, Bak) markers and down-regulated the expression of survival genes (IGF-1, FGF-2, Akt) [48].
Individual Avy mice exhibit high variation in phenotype because the epigenetic state of the IAP is mosaic, and when the IAP is active it transcribes the agouti gene (without any apparent tissue specificity) [11], [15], [29].
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