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In addition, 5-HT2CR null mutant mice exhibit enhanced behavioral responses to novelty and cocaine administration, effects that have been attributed to enhanced dopamine neurotransmission in the NAc [31].

DR6-/ mice exhibit enhanced CD4+ T cell proliferation, Th2 cytokines production and B cell expansion, survival, and humoral responses, which imply that DR6 plays important roles in murine immune responses (Liu et al., 2001; Schmidt et al., 2003).

Activation of PPARα by ligands inhibits inflammation [7] whereas PPARα deficient mice exhibit enhanced inflammation [8].

In order to confirm that GluR5−/− mice exhibit enhanced anxiety levels, we conducted a second behavioral test for anxiety, the light/dark exploration test.

We find that, in response to a temporally restricted feeding schedule, 5-HT2CR null mutant mice exhibit enhanced FAA relative to wild-type mice.

(C ) Slo2.2 KO mice exhibit enhanced responsiveness to CQ injection.

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DOX-loaded vesicles injected into 4T1 tumor-bearing mice exhibited enhanced accumulation in tumor tissue due to the enhanced permeation and retention (EPR) effect.

Behavioral analyses revealed that FSM mice exhibited enhanced anxiety compared to wild-type littermates, while ACM4 mice showed reduced anxiety.

As expected, wild-type mice exhibited enhanced exercise endurance when they were subjected to involuntary high-intensity exercise following the 6-month voluntary training period.

C. jejuni associated IL-10−/−; NF-κBEGFP mice exhibited enhanced EGFP expression (NF-κB activity) over the entire length of the colon as compared to IL-10wt/wt; NF-κBEGFP mice (Fig. 5A).

Compared to the control mice, the diabetic mice exhibited enhanced urinary albumin excretion).

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