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As observed in A-EDMD patients, myonuclei in lmna-null mice exhibit both structural and antigen distribution abnormalities (e.g. LAP2, lamin B, emerin).
However, the D2 knockout (D2KO) mice exhibit both the phenotypes of impaired thermogenic responses to cold and liver steatosis.
We found that db/db mice exhibit, both in plasma and aorta, ADMA levels higher than db/m mice.
Mice with reduced IGF-1 signaling (IGF-1 receptor heterozygous knockout or PAPP-A knockout mice) exhibit both delay in age-related senescent cell accumulation and prolonged lifespan (Holzenberger et al., 2003; Conover & Bale, 2007).
Lungs from control mice exhibit both "big" (defined nodules with one diameter > 5 mm) and "small" (defined as < 5 mm) metastases within the same lungs, big metastases reflecting "false" experimental metastases due to the initial tumor cell injection, and the smaller ones corresponding to newer spontaneous metastases disseminating from the primary tumor.
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Moreover, antigen re-stimulated splenic lymphocytes harvested from immunized mice exhibited both HSV-2 specific CTL activity and IFN-γ expression.
Blood from Vav1-P1cKO micexhibiteded both of these characteristics, demonstrating that Piezo1-deficient RBCs are overhydrated.
DOI: http://dx.doi.org/10.7554/eLife.04617.017 Consistent with a previous report (Storch and Weitz, 2009), Fx/Fx control mice exhibited both free-running activity and FAA in constant darkness.
Omission errors showed significant between-maze effects (F 1,14) = 4.659, p = 0.049), in which mice exhibited both fewer omission errors and shorter trial times in the hexagon maze than the radiolarian maze, with no interaction (F 1,14) = 2.02, p = 0.178; Fig. 4A).
Preinvasive mammary lesions in op/ op mice exhibited both a delayed angiogenic switch and transition to malignancy, whereas genetic restoration of the macrophage population in tumours reversed this [ 4].
In the current study, we further demonstrated that L31/CD4-/ mice exhibited both motor and sensory deficits, including weakness and paresis of limbs, numbness to mechanical stimuli and hypersensitivity to thermal stimulation.
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