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Col25a1−/− mice exhibit a delay in the fusion and organization of myofibers during primary myogenesis.
Surviving mice exhibit a myeloproliferative disorder similar to juvenile myelomonocytic leukemia seen in NF1 patients.
In addition, despite a normal food intake, these mice exhibit a blunted food intake response to leptin administration.
MyD88-knockout MRL/lpr mice exhibit a prolonged lifespan with no apparent development of autoimmune nephritis in comparison with wild-type mice51.
We have found that Krt76-null mice exhibit a marked inflammatory disease phenotype with systemic components: splenomegaly and lymphadenopathy (Fig. 2).
Since we previously demonstrated that these KO mice exhibit a lithium-like neurochemical and behavioral phenotype, here we searched for pathways that may mediate lithium's/the KO effects.
Compared with control animals, PM20D1-KO mice exhibit a variety of metabolic and pain phenotypes, including insulin resistance, altered body temperature in cold, and antinociceptive behaviors.
Dopamine transporter knockout (DAT-KO) mice exhibit a persistent five-fold increase in extracellular dopamine levels.
Yap deficient mice exhibit a dramatic reduction of crypt proliferation, and the ISCs marker Olfm4 is strongly downregulated.
Nr-CAM −/− EphB1 −/− double knockout mice exhibit a larger size of ipsilateral projections (Williams et al., 2006).
The researchers went on to show that if α-Klotho production is inhibited in young mice, those mice exhibit a similar decline in muscle function to ageing mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com