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First, it is difficult to inject small volumes (<10 µl) of intranasal agents in unanesthetized mice, even if they are restrained.
Further, difference in mouse genetic background may raise distinct compensatory mechanism by other UPR pathways between IRE1α and XBP1 CKO mice even if these mice are commonly generated with flox/Cre system.
If ADAM17 degrades Aire protein as part of its normal function, then we might indeed expect to see the levels of Aire protein to be normal in Adam17/Foxn1 mice even if Aire mRNA levels are low, due to an increased lifespan of the Aire protein in the absence of Adam17.
However, the caecal content weight was increased in BaF3-ITF mice, even if these mice ate the same amount of food than BaF3 mice.
In addition, clinical manifestations are different between different strains of mice, even if the same induction protocol is employed, and some of the strains are even selected because of their susceptibility to auto-immunity.
The response to increasing doses of PE (from 10−8 to 10−5 M) was significantly lower in Alk1 +/− than in Alk1 +/+ mice, even if this was corrected by KCl-induced contraction (Fig. 5C,D).
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An elephant is mightier than a mouse, even if the mouse has been working out.
As result we identified an OTX responsive element present in the sequence of different mammalian organism, from human to mouse even if in a different position, meaning that also the element in strand of intron 1 is functionally conserved.
You can still use your mouse even if you have it set to use keypad.
Never put two male mice together even if they are babies, although you can put two to three female mice together just fine (females need a companion. if one female dies the other two have each other).
The pharmacological effects were evaluated against audiogenic seizures in DBA/2 mice and, even if some new derivatives were more active than valproate, the designed modifications did not improve the anticonvulsant efficacy with respect to their precursors.
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