Exact(5)
Furthermore, TAB-ICG administration in MMT mice enabled the detection of lung metastases while sparing recognition of normal epithelia.
Intracranial injection of adeno-associated virus encoding a Cre-dependent (double floxed inverted) Channelrhodopsin2-mCherry fusion protein (DFI-ChR2-mCherry) [25], [26] into the striatum of these mice enabled the CIN-specific expression of the light-activated excitatory ChR2, which was clearly observed 7 14 days after injection (Fig. 1A, see methods).
Comparative analysis in PPAR α-null mice enabled the specific study of the regulatory role of this transcription factor.
Moreover, the postnatal viability of Nrp1 Y297A/Y297A mice enabled the study of newborn and adult mutants, thereby extending genetic evidence for the established function of NRP1 in cardiovascular development to include essential roles in promoting postnatal and pathological angiogenesis.
The phenotypic variation across these mice enabled the identification of eQTL for 14 out of the 40 miRNAs (35%%) that we studied, as well as suggestive eQTL for an additional seven miRNAs.
Similar(55)
Genetic engineering in mice enables the time-controlled labeling and monitoring of lipogenic or myogenic populations of lung fibroblasts during fibrosis formation and resolution.
Labeling and imaging of multiple, individual radial glial cells with this approach in Dlx5/6-CIE mice enables the real time analysis of radial glia-interneuron interactions all across the developing cerebral wall.
Monocolonization of germ-free (GF) mice enables the study of specific bacterial species in vivo.
(iv) Finally, the Staudinger ligation was performed in live mice, enabling the selective in vivo covalent modification of cell-surface glycans with chemical probes.
Relevance of CXCR7/CXCR7 ligands for CRC metastasis was then investigated in mice using small pharmacological CXCR7 antagonists and CRC cell lines of human and murine origins, which – injected into mice – enable the development of lung and liver metastases.
Finally, the TAP MS approach applied to transgenic mice enables the comparison of protein complex organization between different tissues, facilitating the characterization of novel interacting partners not previously identified in cell cultures [ 45].
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