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Spatial memory deficits were observed in IDUA−/− mice during both 1 and 7 days probe trials at 4 and 8 months of age.
CrT+/y and CrT−/y mice showed equivalent preference for stranger mice during both phases.
MCAs were reduced the most in resin-fed mice during both fasting (10 00) and feeding (22 00) phases.
The Th17 cell population in peripheral lymphoid tissue remained elevated in sham treated EAE mice during both the early and late stages of EAE (Fig. 5b), as expected.
Exploration time was lower with the transgenic mice than with wild-type mice, and lower with GTP-treated mice than with water-fed mice during both the acquisition and retention sessions.
Nevertheless, inhibition of GSK3 by lithium administration reduced anxiety-related behaviors during social interaction in both wild-type and Fmr1 knockout mice during both the sociability and social preference periods of testing.
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We envision that lentiviruses will become valuable tools to study Wnt and other signaling pathways, allowing us to dissect ligand-receptor interactions as we seek to further understand the intricacies of signaling within the mouse during both development and in disease.
Mice were housed in clear polypropylene cages juxtaposed to each other such that they could see other mice both during normal housing as well as during video recordings.
The main finding of this study was a significantly reduced ASM relaxation in p47phox-/ compared with wild-type mice both during the stimulus and after the end of stimulation.
As already reported for Lurcher mice [19], motor performance and learning deficits in TgIE96 mice were more evident for skeletal muscles than for the facial motor system, since the learning curves displayed by these mice during classical conditioning (using both trace and delay paradigms) of eyelid responses were similar to those of controls.
However, in our experiments, plasma corticosterone concentrations were barely increased in unstressed h IL6tg mice compared with control mice and increased equally in both mice during stress (data not shown).
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