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We found that changes in BM progenitor numbers in tumor-free mice dosed with GCSF mice paralleled those observed in tumor-bearing mice.
Antibody neutralization assays have been applied previously to mice dosed with BoNT [25].
No difference in onset or disease severity was observed between mice dosed with PBS and treated with the different combinations of mAbs, except those mice dosed with PBS + anti-TGF-β mAb recovered sooner from the acute disease (Figure 5B).
After 24 hpi, we could not detect the ricin in feces in mice dosed with 200 µg/mouse or less.
The resultant protection of dystrophin-deficient fibres by continued expression of utrophin resulted in a reduction in the level of regeneration taking place in skeletal muscle in mdx mice dosed with SMT C1100.
In mice dosed with lolitrem B, heart rate was decreased by 42% 2 h after treatment which persisted for a further 8 h, followed by a slow recovery over 4 days (Fig 1C).
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HDM sensitised control mice were dosed with control mouse IgG (10 mg/kg mAb 101.4) accordingly.
However, adult male mice dosed for 24 h with MEHP (0.5 mg/kg of b.w).
Preventative studies involving bacteria pre-dosing: five mice were dosed once daily by oral gavage with MRx0004 (5 × 108 CFU/mouse) and another five mice were dosed with vehicle (YCFA; 400 µL/mouse) from D-14 to D17.
In experiments 1 and 2, mice were dosed with morphine (10 mg/kg, i.p).
Five mice were dosed with 12.5 mg/kg anti-IL-17 neutralizing antibody on D13, D15 and D17 by i.p. injection.
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