Sentence examples for mice disruption of from inspiring English sources

Thus,despite maintenance of robust core circadian clock function in non-resonant mice, disruption of timing was evident in a number of key clock-output pathways.

In mice, disruption of Lrp6 causes severe developmental defects [13].

In mice, disruption of any subunit of the MRN complex results in embryonic lethality [22] [24].

In mice, disruption of the DAZL gene leads to loss of germ cells and complete absence of gamete production [25].

Support for the role of CLOCK in the behavioral activity is provided by a study in which another CLOCK variant, rs1801260 (T311C), was linked to the diurnal activity levels in depressed patients [49], [50], and on the other hand in mice disruption of CLOCK contributes to overactive or manic-like behavior [51].

Acute disease pathology was not observed in IL-6KO mice treated with LPS or CB3 alone indicating that, as with wt mice, disruption of IL-6 does not alter the general immune response enough to allow LPS or CB3 alone to cause disease (Figure 1a).

In both zebrafish and mouse, disruption of endothelin1 (edn1) causes a loss or transformation of the lower jaw (Nair et al., 2007; Tavares et al., 2012).

If the efforts at generating mouse disruptions of the lipoic acid synthase gene Lias are in any way instructive to evaluating the chances for success at rapidly generating a FASII knockout mouse, then this does not bode well as these attempts have so far only led to embryonic lethality [34], precluding thorough investigations on live knockouts.

Comparison of confocal images from motor cortex of cMSUD and heterozygous mice shows disruption of neurofilaments and reactive astrocytosis in cMSUD mice at 3 days of age (Fig. 4A and B).

Elimination of PF4 reduces atherosclerotic lesion size in ApoE−/− mice and disruption of PF4 and RANTES complexes can also reduce atherosclerosis in this mouse model [40], [41].

Suzuki, H. et al. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase.