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In addition, while full-length tethered MMP16 failed to alter gelatinase activity, a 50% increase occurred after injection of the soluble form [23]. MMP16 was recently shown to act as a major collagenolytic enzyme in bone and cartilage during mammalian embryogenesis, with MMP16-deficient mice displaying delayed skeletal growth [24].
PLAU is a critical regulator in tissue remodeling and angiogenesis, with PLAU-deficient mice displaying delayed wound healing, decreased keratinocyte migration required for re-epithelialization, and impaired angiogenesis.
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Furthermore, in vivo, B-lymphocytes from Bcl-2 transgenic mice displayed delayed activation following immunization [27].
However, Olig1−/− mice displayed delayed onset of EAE, and the clinical signs of Olig1−/− EAE mice became comparable with WT EAE mice only in the late phase.
FbnC1039G/+/ βarr2−/− mice displayed delayed aortic root dilation compared with FbnC1039G/+ mice.
We demonstrate that FbnC1039G/+/βarr2 deletion (βarr2−/−) mice display delayed aortic root dilation compared with FbnC1039G/+ mice.
BALB/c-TP53 null mice displayed delayed involution of the mammary epithelium [ 56].
In particular, we observed that FbnC1039G/+/ βarr2−/− mice display delayed aortic root dilation relative to FbnC1039G/+ mice.
Despite no significant differences in accumulating TAMs in WT animals, IL-4Rα−/− mice displayed delayed tumor growth.
In addition, cardiac glucose consumption as determined PET was not altered by aging in the mutant model, indicating that RasGrf1-deficienct mice display delayed aging.
Recently, FXR was found to modulate glucose absorption in the proximal intestine, since FXR-deficient mice displayed delayed glucose absorption (37).
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