However, a number of heterozygous MeCP2-null female mice displayed some RTT features at a later stage (Chen et al. 2001; Guy et al. 2001).
Although kalata B1-treated mice displayed some improvement in disease severity, inflammatory lesions, demyelination, and axonal damage and/or loss were disseminated throughout the spinal cord.
We found that Fra-1∆/∆ mice displayed some of the factors that contribute to pulmonary fibrosis, such as increased expression of pro-inflammatory genes and decreased expression of genes involving in apoptotic process during bleomycin treatment.
Sle3 mice display some autoimmune features but do not develop glomerulonephritis.
The mice display some features of GD, such as systemic inflammation, anaemia, skin abnormalities and depressed serum cholesterol levels (Mizukami et al., 2002).
Whereas the Kras-mutant mice largely phenocopy the Shp2-mutant mice (Hernández-Porras et al., 2014; Tuveson et al., 2004), the Sos1- and Raf1-mutant mice display some unique features.
Because the parental NZB and NZW mice display some autoimmune features, we chose as controls two non-autoimmune strains of mice, B6 and BALB/c, which in the literature are the most commonly used for comparison with NZM2410 [ 20, 21] and NZB-W/F1 mice [ 12, 22], respectively.
The white matter of thoracic spinal cord of βLKB1KO mice displayed morphological changes, displaying some of the characteristics of axon degeneration: large foci of disrupted, vacuolized and demyelinated axons with disorganized microtubules.
However, SIRT1 overexpression in those mice displayed improvement of some age-associated phenotypes, such as wound healing, decreased tumorigenicity, better maintenance of glucose homeostasis and others.
Using a similar strategy for generation of Hand1 TG mice, we obtained Twist1-WT and -DD transgenic TG mice and found that while -WT TG mice had comparable heart to control mice, Twist1-DD TG mice displayed hypertrophy and some of them had atrial septal defect (ASD) and ventricular septal defect (VSD) (Figure 2B D).
Some mice displayed tumors in multiple mammary glands, although the majority (59%) of mice had a single mammary tumor.
