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Vehicle treated nicotine withdrawn mice displayed significant anxiety-related behavior, somatic signs, hyperalgesia, and CPA.
Dys−/− mice displayed significant learning deficits and required more trials to acquire this task.
However, TTC9A−/− female mice displayed significant increase in immobility (t(18) = −3.342, p = 0.004) and time-spent in the corner zone (t(16) = −2.867, p = 0.011) compared to the TTC9A+/+ mice (Fig. 4C,F), indicating anxiogenic response.
LPS and UCMS exposed mice displayed significant coat state deterioration (UCMS factor H (7) = 37.5, p < 0.0001) and locomotor hyperactivity in a novel arena (UCMS factor F (1,74) = 20.8, p < 0.0001).
Our previous work showed that 7 month old human apoE4 targeted replacement (TR) mice displayed significant synaptic deficits in the principal neurons of the lateral amygdala, a region that is critical for memory formation and also one of the primary regions affected in Alzheimer's disease, compared to apoE3 TR mice.
The STZ plus insulin treated mice displayed significant recovery in the axonal transport rates, Figure 1B.
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Importantly, coilin knockout mice display significant fertility and fecundity defects.
We have shown that Coil −/− mice display significant viability defects.
Finally, we show that Coil −/− mice display significant fertility and fecundity defects as compared to controls.
Remarkably, ISRIB-treated mice display significant enhancement in spatial and fear-associated learning.
These data indicate that APΔE9 mice display significant deficits in learning skills at 12 months of age and that RanBP9 further exacerbate this deficit.
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