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Female C57 and LID mice displayed lower body, heart and liver weights compared to male counterparts.
Interestingly, ribavirin-treated mice displayed lower LVTs than that of zanamivir-treated animals, but the values were not statistically significant (P > 0.5) (Fig. 1C).
However, αCGRP knockout mice displayed lower pain sensitivity to heat stimulation faster accumulation of c-Fos compared to wild-type animals after incision and complete Freund's adjuvant injection [104].
Furthermore, lymph nodes taken from AnxA1null mice displayed lower SGPP2 gene activity.
CAG200 mice displayed lower grip strength and reduced locomotor activity, indicating that these mice may have muscle weakness and altered energy metabolism.
Compared to wild-type, hippocampal neurons from Gpr3−/− mice displayed lower basal intracellular cAMP levels, consistent with the strong constitutive activity of GPR3 in transiently transfected cells.
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Moreover, DAT-KO mice display lower peak HTO frequencies than WT mice during periods of REM sleep where both genotypes of mice are behaviorally inactive.
Here, we demonstrate that DAT-KO mice display lower hippocampal theta oscillation frequencies during baseline periods of waking and rapid-eye movement sleep.
Diurnal variations in HR and BP closely followed the activity profiles of animals of the respective genotypes, with Vipr2−/− mice displaying lower average levels of HR and BP than WT in the last 8 h of the dark period (Figure 1a f).
These mice display lower plasma levels of IGF-1, lower oxidative stress and a metabolic profile which resembles that observed in calorie-restricted wild-type animals.
In contrast, DMH/LH-specific Nkx2-1 or Sirt1-knockdown mice (Satoh et al., 2013) and DMH-specific Prdm13-knockdown mice display lower NREM delta power compared to controls.
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