Furthermore, P2X7R−/− mice display intact performance in an object recognition task with the same 30-min ITI, suggesting that memory is not affected in a non-spatial task.
Interestingly, Y1 receptor KO mice display intact, but significantly delayed extinction, whereas Y2 receptor KO mice did not behave differently in this respect from control mice.
However, the supplementation with exogenous IL-2 could only partially rescue thymic Treg cell numbers, although thymocytes from IκBα-SR Tg mice displayed an intact IL-2R signaling.
As expected, naive control mice displayed an intact colonic epithelium and cytoplasmic β-catenin localization and proliferating cells were confined to the crypt base.
All control cases displayed intact neocortical myelin.
Intact female mice displayed slightly higher GPx activities than intact male mice.
In summary, the R306C Tg mice displayed no phenotypes, indicating that the TRD and C-terminus must be intact to observe the toxic effects of doubling MeCP2.
By contrast, at 1 week after treatment, the TNFα-treated ΔCS mice displayed a significant loss of nerve fibers (Figure 3D), with some mice displaying very few intact axons (Figure 3E).
Untreated mice displayed extensive callosal demyelination (Fig. 2a, d), whereas mice treated with 25 mg/kg showed mainly intact callosal myelin with only focal signs of demyelination (Fig. 2c, f).
