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In biodistribution studies using normal mice, [125I]6 and [125I]9 examined in normal mice displayed high brain uptakes with 4.9 and 2.8%ID/g at 2 min post injection.
Moreover, Pisetsky et al reported that female mice displayed high levels of circulating DNA [8].
Microcomputed tomography (micro-CT) and bone histomorphometry analyses showed that Cthrc1-null mice displayed low bone mass as a result of decreased osteoblastic bone formation, whereas Cthrc1 transgenic mice displayed high bone mass by increase in osteoblastic bone formation.
Wild-type mice displayed a mild response to seizure-induced cell death, however conversely, GalR1−/− mice displayed high susceptibility to seizure-induced cell death induced by the same dose of KA.
Sam68-deficient mice displayed high lethality soon after birth [ 28].
These mice displayed high mutation rates accompanied by increased frequencies of colorectal adenomas and carcinomas [ 16].
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In opposite to Jak2−/− mice, Stat5-Tg mice displayed higher DC yield, larger spleen size and higher potency in response to LPS stimulation (Figure 6).
CY-treated R4A Tg mice displayed higher titers of anti-DNA antibodies at 28 days than PBS-treated R4A Tg mice (Figure 5A).
Intraperitoneal glucose tolerance testing demonstrated that caCnRIP mice displayed higher glucose levels after 30 and 60 minutes after glucose injection (Figure 2C).
While mice of both genotypes had comparable swim speed and thigmotaxis (both parameters p>0.2), KO mice displayed higher accelerations during progression segments (p<0.05) and a high rate of 360°-rotation of the animal's body (p<0.0001), suggesting darting or impulsive-like responses and increased path tortuosity.
It is important to note that these alterations in social behaviors were not confounded by reduced levels of general exploration or activity: during trial 2 of the three compartment test R6/1 mice displayed higher levels of locomotion and a similar overall exploration of the social and non-social stimuli compared to their wild type littermates.
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