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Firstly, we used the novel object recognition test and observed that these mice displayed completely normal behavioral performances in the 1 day retention tests as compared to their wild-type littermate control (Figure 1E).
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The flag should be displayed completely spread out with the saffron stripe on top.
More importantly, these mice displayed severe weight loss before becoming completely moribund and immobile, at which point they had to be humanely euthanized.
After intraperitoneal injection of heat-killed pneumococci in vivo, however, TLR2KO mice displayed unaltered proinflammatory cytokine gene expression in their spleens, whereas MyD88KO mice had virtually completely lost their ability to mount a splenic cytokine response [ 24].
When CS+ and CS− were represented by two different auditory stimuli, NPY KO mice displayed an increased freezing response to the CS−, whereas both WT and NPY KO mice were able to differentiate between two completely different stimuli, such as a visual and an auditory stimulus.
Following sepsis induction, however, HDC−/− mice displayed an evidently lower levels of those cytokines compared with WT mice.
For example, grooming during Open Field and Hole Board tests was almost completely suppressed in mutant compared to control mice (Fig 8B, p = 0.001), while in the safety of their home cages, mutant mice displayed normal grooming behavior.
Additionally, the mice displayed no overt phenotypic differences.
In contrast, both mice displayed increased expression of NR1, but Prnp −/− displayed enhanced NR2B expression.
The hSAA transgenic mice displayed no visible phenotype.
Treated mice displayed slightly lower parasitemia levels (Fig. 4D).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com