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Furthermore, CA-Rac1 group mice displayed complete disorganisation or even loss of cartilage structure.
Notably, two of the seven co-treated mice displayed complete tumor regression (CR) by the end of the dosing cycle (Supplementary Figure S1).
Consistent with these findings, 50% of the supplemented mice displayed complete cortical bridging, whereas most of the non-supplemented OVX mice were 'not healed' (Fig. 7F).
In addition to the above changes, βLKB1KO mice displayed complete loss of control of their tails 1 2 weeks after the initial onset of the hind-limb dysfunction (Fig. 1A).
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Finally, in the CT-26 colon carcinoma model, the combination of ixabepilone or paclitaxel with anti-mCTLA-4 mAb resulted in effective tumor rejection, with 50 70 % (n = 5/10 and 7/10, respectively) of mice displaying complete tumor regression (Table 1; Fig. 1f).
The mammary glands of ovariectomized C57Bl6 mice displayed almost complete developmental arrest, whereas those of their CD-1 counterparts maintained a few TEB structures.
Like mouse ES cells, iPS cells from both line 11.1 and line 4.1 displayed complete demethylation at the endogenous Oct4 promoter, indicating that full reprogramming occurred.
However, all of the mice in the gemcitabine treatment group (n = 2) and all of the mice treated with gemcitabine plus anti-mCTLA-4 mAb (n = 5) that initially displayed complete regressions rejected subsequent tumor rechallenge (Table 1).
However, unexpectedly, rTgTauEC x APP/PS1 mice displayed a nearly complete reduction in the number of FISH-positive cells compared with mice expressing rTgTauEC only.
The observation that mice with a selective ablation of the androgen receptor (AR) in Sertoli cells (SC) (SCARKO mice) display a complete block in meiosis supports the contention that SC play a pivotal role in the control of germ cell development by androgens.
Likewise, TP53−/− rescued XRCC4 KO mice display a complete absence of mature lymphocyte development owing to their impaired V(D J recombination, a trait accompanied by the onset of aggressive pro-B-cell lymphomas, revealing the role of XRCC4 as an important genome caretaker.
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