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Additionally, autophagy-deficient mice displayed a significantly greater inflammatory response after bleomycin treatment18,19.
Notably, Ap4-deficient mice displayed a significant decrease in the number of ISCs positive for Olfm4 mRNA expression (Fig. 6c).
Upon awakening, transgenic and control mice displayed a similar rate of increase in locomotion and food/water intake with time.
Maged1-deficient mice displayed a significant osteoporotic phenotype with a marked decrease in bone density and deterioration of trabecular architecture.
The Δ1-158 Δ1-158isplayed a heightened sensitivity to shock at 8 weeks, but not at 8 micehs of age.
C3GnT-deficient mice displayed a discrete, colon-specific reduction in Muc2 protein and increased permeability of the intestinal barrier.
MTKO mice displayed a significantly higher humoral response to challenge with ovalbumin (OVA) compared to wild-type controls.
ThymoD-deficient mice displayed a block at the onset of T cell development and developed lymphoid malignancies.
As previously described17, DAT-KO mice displayed a perseverative pattern of locomotor activity known as 'thigmotaxis' when tested in an open field28.
(b) In the Morris water maze paradigm, 12-month-old Tg2576 mice displayed a significant spatial learning impairment compared with their littermate controls (n=9/group).
Interestingly, AC8 transgenic mice displayed a significantly greater increase in cardiac contractility and improved active phase of relaxation.
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