The remaining mice displayed strong signals in the whole body (Figure 3A, lower panel), with high bacterial blood counts, indicating fulminant bacteremia.
After stimulation with PMA plus ionomycin, Thy1.1+ T cells from control mice displayed strong production of IFN-γ, however tolerised T helper cells virtually did not respond to this direct activation stimulus (Figure 1E).
Consistently with this hypothesis, recent work has demonstrated that ERK2-knockdown mice display a strong impairment of long term memory in fear conditioning, while short term memory is not affected [50].
We observed that MMP13−/− mice display a strong protection in LPS- and caecal ligation and puncture-induced sepsis.
As shown in Fig. 2A and C, CD4+ T cells from nonhealing BALB/c mice display a strong polarized Th2-type response with high iMFI for CD4+IL-4+, but low iMFI for CD4+IFN-γ+; they also clearly produced the regulatory cytokine IL-10; in contrast, the cytokine profile of CD4+ T cells from healer CBA mice is clearly Th1-type, with high iMFI for IFN-γ and lower iMFI for IL-4 and IL-10 (Fig. 2B and C).
Among single Syn KO mice, SynII−/− mice display the strongest phenotype, although the mechanisms underlying these behavioral differences are still unclear.
These inbred mouse strains have been used as a genetic animal model of depression-like behaviour and are characterized by a different stress-responsiveness, since DBA/2J mice display a stronger behavioural response to stressful conditions [ 22, 23, 29].
Itrybe-loaded NPs display strong fluorescence signals in vitro and in vivo and Herceptin-conjugated NPs bind specifically to HER2 as demonstrated in immunoassays as well as on tumor cells and sections from mouse tumor xenografts in vitro.
They display strong tissue-specificity in local chromatin interactions.
